Fabian Rieder, Johan Manzambi and Dan Ndoye were all on target as Murat Yakin's side recorded a fourth consecutive victory in Group B1.
Rieder breaks the deadlock
Switzerland dominated the contest and eventually found the breakthrough in the 43rd minute.
Fabian Rieder scored to give the hosts a 1-0 lead just before half-time, sending Switzerland into the interval in control of the match.
North Macedonia had already suffered three defeats in their opening group matches and struggled to contain a Swiss side that had won their previous meetings with them and Scotland by 3-0 margins.
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Manzambi doubles Switzerland's lead
Switzerland continued to control the game after the restart and were rewarded again in the 73rd minute.
Johan Manzambi found the net to double the hosts' advantage and put the result beyond serious doubt.
The goal capped another impressive attacking display from Switzerland, who had already scored three goals against North Macedonia in the reverse fixture in September.
Ndoye completes comfortable victory
Switzerland added a third goal eight minutes later.
Dan Ndoye scored in the 81st minute to complete a 3-0 victory and give the hosts another clean sheet.
The result was confirmed by the Swiss Football Association, which recorded the goals by Rieder, Manzambi and Ndoye.
Switzerland 3-0 North Macedonia
• Switzerland: Fabian Rieder 43', Johan Manzambi 73', Dan Ndoye 81'
• North Macedonia: No goals
Switzerland remain perfect in Group B1
The victory leaves Switzerland with 12 points from four matches, having won every game without conceding a goal.
Their campaign began with a 3-0 away victory over North Macedonia, followed by another 3-0 win against Scotland and a 2-1 victory over Slovenia. Tuesday's result completed a remarkable four-match winning run.
North Macedonia, meanwhile, remain without a point and have yet to score in the group.
Promotion hopes strengthened
Switzerland's flawless record puts them firmly in control of Group B1 as they pursue promotion from League B.
Their remaining fixtures will see them travel to face Slovenia on 13 November before hosting Scotland on 16 November.
With four wins from four, Yakin's side have given themselves an excellent platform heading into the final two rounds of the Nations League league phase.