A. Brika scored in the seventh minute. S. Allouch added a second before half-time. A. Ouédraogo pulled one back for Rahimo in the 60th minute. D. Titus and Christopher Ibayi finished the scoring in the 72nd and 76th minutes at the Complexe Sportif de Fès.
15 de Agosto v Fomboni remains postponed.
Friday, 4 September
- AS Port 1-2 Zamalek
- Asswehly 1-0 KVZ
- JS Saoura 1-0 Horoya
Saturday, 5 September
- Aigle Noir 0-2 Al Hilal
- El Merriekh Bentiu 1-0 Heegan
- CFFA 2-0 Lijabatho
- Mangasport 3-1 African Stars
- Aiglons 0-0 Sidama Bunna
- Canchungo 0-1 Teungueth
- San Pedro 1-1 Rivers United
- Star Sport Academy 0-0 Medina United
- Vipers 1-1 Nouadhibou
- Al Merreikh 1-0 Power Dynamos
- Gaborone United 1-1 Young Africans
- Club Africain 1-0 Djoliba
Sunday, 6 September
- La Cure Waves 0-0 Orlando Pirates
- Gor Mahia 0-2 Pyramids
- Aigles du Congo 1-0 APR
- Mighty Wanderers 0-1 Simba
- Scottland 1-0 Nsingizini Hotspurs
- UD Songo 0-1 Petro de Luanda
- Colombe 0-0 Stade Malien
- Medeama 0-1 TP Mazembe
- Rangers International 1-1 AS Sobemap
- Wiliete 4-0 Foresters
- ASC Kara 1-1 ASEC Mimosas
- Nigelec 0-0 MC Alger
- Maghreb de Fès 4-1 Rahimo
The second legs are due next weekend. Away goals already hang over several ties involving Nigerian, Kenyan, Malawian, Zambian and Mauritian clubs. Fès and Wiliete hold the two largest first-leg cushions. The postponed Angolan–Comorian fixture will be rearranged by CAF.