Completed ties
| Second leg | Agg. | Qualifier |
|---|---|---|
| Foresters 0-1 Wiliete | Wiliete 5-0 | Wiliete (to face Mamelodi Sundowns) |
| Zamalek 4-0 AS Port | Zamalek 6-1 | Zamalek |
| MC Alger 5-0 Nigelec | MC Alger 5-0 | MC Alger (to face Rangers) |
| Djoliba 2-2 Club Africain | Club Africain 3-2 | Club Africain |
| Medina United 1-1 Star Sport Academy | 1-1 (Star Sport away goals) | Star Sport Academy |
| APR 3-0 Aigles RDC | APR advance | APR |
| Al Hilal 1-0 Aigle Noir | Al Hilal advance | Al Hilal |
| Power Dynamos 0-1 Al Merrikh | Al Merrikh advance | Al Merrikh |
| Heegan 0-3 El Merriekh Bentiu | El Merriekh Bentiu advance | El Merriekh Bentiu |
| Orlando Pirates 3-1 La Cure Waves | Pirates advance | Orlando Pirates |
| African Stars 2-0 Mangasport | African Stars advance | African Stars |
| Young Africans 2-1 Gaborone United | Yanga advance | Young Africans |
| TP Mazembe 3-1 Medeama | Mazembe advance | TP Mazembe |
| 15 de Agosto 4-0 Fomboni | 15 de Agosto advance | 15 de Agosto |
| Petro de Luanda 2-2 UD Songo | Petro go through on aggregate from first-leg advantage | Petro de Luanda |
| AS Sobemap vs Rangers | Rangers won on penalties | Rangers International |
Zamalek’s four goals included a Abdallah El Said hat-trick. MC Alger’s scorers included Konate, an own goal, Bangoura, Boukholda and Nduwumwe.
Sunday second legs still to play
- KVZ vs Asswehly
- Sidama Bunna vs Aiglons
- Simba vs Mighty Wanderers
- Rivers United vs San Pedro
- ASEC Mimosas vs ASC Kara
- Horoya vs JS Saoura
- Stade Malien vs Colombe
- Nouadhibou vs Vipers
- Pyramids vs Gor Mahia
- Teungueth vs Canchungo
Winners progress to the second preliminary round (16–18 and 23–25 October). Defending champions Mamelodi Sundowns, Espérance de Tunis and RS Berkane already hold byes into that stage.