Goalkeeper Emiliano Martinez has been selected between the posts, while centre-back Levi Colwill will captain the side under manager Xabi Alonso.
The Blues line up as follows: Martinez; Fofana, Lacroix, Colwill, Neto, Gusto; Lavia, Hato; Palmer, Rogers, Joao Pedro.
Among the substitutes are Penders, Acheampong, Chavarria, James, Barco, Caicedo, Estevao, Gittens and Welbeck.
Speaking ahead of the match, Alonso emphasised the importance of consistency as his side look to build on their early-season form.
“Now is the time to deliver and the time to show it every weekend,” the Chelsea manager said.
Chelsea host Brighton at 14:00 WAT as part of a busy Sunday of Premier League action. The home side will be aiming to secure a positive result in front of their supporters, while Brighton travel to west London looking to cause an upset.
The match forms part of Matchday 2, with several other fixtures also taking place across the country this afternoon.