The Tanzanian giants have collected just two points from two matches, with one group fixture remaining against Singida Black Stars. Even a victory in their final game would take them only to five points.
That total will not be enough to finish as one of the best second-placed teams and progress to the semi-finals, with Al Hilal and Rayon Sports already on six points.
It has been a disappointing campaign for Simba, who leave the tournament earlier than expected.