The Boston Celtics also recorded an emphatic 119-80 win over the Charlotte Hornets, while the San Antonio Spurs and Oklahoma City Thunder secured convincing victories against the Sacramento Kings and Memphis Grizzlies respectively.
Dončić leads Lakers past Trail Blazers
Dončić produced 53 points, five rebounds and five assists as the Lakers overcame Portland 124-118 at home to claim their fourth consecutive victory.
The Lakers had to recover from a difficult start after falling 16 points behind in the second quarter.
Dončić helped reduce the deficit with an extraordinary shot from beyond half-court just before half-time, giving his team momentum for the second half.
Portland threatened a late comeback, cutting the deficit to four points in the final minute, but Dončić responded with a crucial floater to help the Lakers secure the win.
The performance marked the 11th 50-point game of his NBA career and his fourth since joining the Lakers.
Cavaliers end 76ers’ winning run
The Cleveland Cavaliers defeated the Philadelphia 76ers 119-95 at Rocket Arena, bringing Philadelphia’s five-game winning streak to an end.
The game also marked LeBron James’ first return to Cleveland as a 76ers player following his move from the Lakers during the off-season.
James endured a difficult night, finishing with eight points, seven rebounds, three assists, two steals and six turnovers after shooting three-of-12 from the field.
Donovan Mitchell led Cleveland with 23 points, seven rebounds and eight assists, while Evan Mobley contributed 22 points.
Jaylen Brown scored 20 points for Philadelphia, but Joel Embiid struggled offensively, missing all nine of his field-goal attempts and finishing with six points.
The Cavaliers controlled much of the contest and outrebounded the 76ers 56-42.
Celtics demolish Hornets
The Boston Celtics produced one of their most dominant performances of the season, overwhelming the Charlotte Hornets 119-80 on the road.
Jayson Tatum led the Celtics with 34 points, eight rebounds and nine assists, while Derrick White contributed 18 points.
Boston made 24 of its 44 attempts from three-point range and built a lead of as many as 46 points.
The Celtics took control early, establishing a 40-20 advantage by the end of the first quarter before maintaining their dominance throughout the contest.
Wembanyama powers Spurs past Kings
Victor Wembanyama recorded 30 points and 14 rebounds as the San Antonio Spurs defeated the Sacramento Kings 124-109.
The French centre continued his impressive form following his remarkable 52-point, 24-rebound performance against Dallas in his previous outing.
San Antonio controlled the contest to begin its NBA Cup group-stage campaign with a victory.
Thunder dominate Grizzlies
The Oklahoma City Thunder continued their strong run against Memphis with a commanding 128-97 victory over the Grizzlies.
Ajay Mitchell delivered a career-high 35 points, while reigning two-time NBA Most Valuable Player Shai Gilgeous-Alexander added 28.
The Thunder established a 71-49 half-time advantage and maintained their control after the break.
The victory marked Oklahoma City's 13th consecutive regular-season win over Memphis.
Friday's NBA results
• Los Angeles Lakers: 124-118 Portland Trail Blazers
• Cleveland Cavaliers: 119-95 Philadelphia 76ers
• Boston Celtics: 119-80 Charlotte Hornets
• San Antonio Spurs: 124-109 Sacramento Kings
• Oklahoma City Thunder: 128-97 Memphis Grizzlies