The Jaguars made an excellent start, taking the lead through Bhayshul Tuten, who completed a seven-play, 77-yard opening drive with a one-yard touchdown run.
Baltimore responded with a 53-yard field goal from Jake Moody to reduce the deficit to 7-3, but Jacksonville extended its advantage through Cam Little's 36-yard field goal.
Quarterback Trevor Lawrence then connected with Parker Washington for a 50-yard touchdown with 58 seconds remaining in the second quarter, sending Jacksonville into half-time with a commanding 17-3 lead.
The Ravens struggled to find an answer after the restart, particularly with rookie quarterback Joe Fagnano making his first NFL start in the absence of Lamar Jackson and Tyler Huntley, both sidelined through injuries.
Fagnano endured a difficult evening, throwing two interceptions as Jacksonville's defence continued to dominate.
Little added three more field goals, from 45, 47 and 33 yards, to extend the Jaguars' advantage to 26-3.
Jacksonville then capitalised on a Baltimore fumble, with Chris Rodriguez Jr. scoring a two-yard rushing touchdown to make it 33-3.
The Ravens managed a consolation score through Justice Hill, who broke away for a 65-yard touchdown run with just over seven minutes remaining.
However, it was too late to inspire a comeback as Jacksonville comfortably secured the victory.
Jaguars strengthen AFC South position
Lawrence finished with 242 passing yards and one touchdown, completing 16 of his 26 attempts.
Washington was among the standout performers with his 50-yard touchdown reception, while Tuten and Rodriguez contributed rushing touchdowns.
Little also played an important role, converting all four of his field-goal attempts.
For Baltimore, Fagnano completed 10 of 18 passes for just 60 yards and threw two interceptions. Hill finished with 85 rushing yards and a touchdown, while Derrick Henry added 57 rushing yards.
The Jaguars improved to 6-2, strengthening their position at the top of the AFC South, while the Ravens dropped to 4-5 after suffering their fourth straight defeat.
Baltimore have now been outscored 117-43 during their four-game losing streak, highlighting the extent of their recent struggles.
Final score: Jacksonville Jaguars 33-10 Baltimore Ravens