Sundowns appeared to be in control after taking a two-goal lead in the first half, but Chiefs responded with four unanswered goals to maintain their winning start to the reserve league campaign.
Sundowns take command
Mamelodi Sundowns made the stronger start and established a 2-0 advantage before half-time.
Simphiwe Mlondo opened the scoring before Lehlohonolo Mahlangu doubled Sundowns' lead, leaving Chiefs facing a difficult task after the interval.
Chiefs complete remarkable turnaround
Chiefs responded impressively after the break, with Neo Bohloko leading the comeback.
Bohloko scored twice to complete his second consecutive brace, while Samkelo Msimango and Benjamin Eliyahu also found the net as Amakhosi overturned the deficit and secured a 4-2 victory.
• Mamelodi Sundowns: Simphiwe Mlondo, Lehlohonolo Mahlangu
• Kaizer Chiefs: Neo Bohloko 2, Samkelo Msimango, Benjamin Eliyahu
Chiefs maintain perfect start
The victory means Chiefs have won their opening two DStv Diski Challenge matches of the campaign.
They had begun the season with a 3-2 victory over Soweto rivals Orlando Pirates before producing another impressive result against Sundowns.
Sundowns, meanwhile, suffered their first defeat after opening their campaign with a victory over Durban City.
Other results
Several other matches were played across the DStv Diski Challenge over the weekend.
• Orlando Pirates: 4-1 Stellenbosch FC
• Siwelele FC: 2-0 Chippa United
• AmaZulu: 2-0 Richards Bay
• TS Galaxy: 1-0 Durban City
• Milford: 3-1 Kruger United
• Sekhukhune United: 1-1 Marumo Gallants
• Golden Arrows: 3-2 Polokwane City
The result underlines Chiefs' strong early form and gives them significant momentum as the DStv Diski Challenge campaign continues.