All times are in West Africa Time (WAT).
Friday, 18 September
- 20:00 — Espanyol vs Elche (RCDE Stadium)
Saturday, 19 September
- 13:00 — Osasuna vs Rayo Vallecano (El Sadar)
- 15:15 — Athletic Club vs Alavés (San Mamés)
- 17:30 — Celta Vigo vs Racing Santander (Balaídos)
- 20:00 — Sevilla vs Barcelona (Ramón Sánchez-Pizjuán)
Sunday, 20 September
- 13:00 — Getafe vs Málaga (Coliseum)
- 15:15 — Atlético Madrid vs Real Madrid (Riyadh Air Metropolitano)
- 17:30 — Deportivo La Coruña vs Real Betis (Riazor)
- 17:30 — Villarreal vs Levante (Estadio de la Cerámica)
- 20:00 — Valencia vs Real Sociedad (Mestalla)
The standout fixture is the Madrid derby on Sunday afternoon, while Barcelona’s trip to Sevilla on Saturday evening also carries significant weight early in the campaign.