Completed ties
| Second leg | Aggregate | Qualifier |
|---|---|---|
| Wiliete 1-0 Foresters | Wiliete 5-0 | Wiliete (vs Sundowns) |
| Zamalek 4-0 AS Port | Zamalek 6-1 | Zamalek (vs APR) |
| MC Alger 5-0 Nigelec | MC Alger 5-0 | MC Alger (vs Rangers) |
| Pyramids beat Gor Mahia | Pyramids 7-1 | Pyramids |
| Simba 6-1 Mighty Wanderers | Simba 7-1 | Simba |
| Young Africans 2-1 Gaborone United | Yanga 3-2 | Young Africans |
| Al Hilal 1-0 Aigle Noir | Al Hilal 3-0 | Al Hilal |
| Heegan 0-3 El Merriekh Bentiu | El Merriekh 4-0 | El Merriekh Bentiu |
| KVZ 0-3 Asswehly | Asswehly 4-0 | Asswehly |
| Sidama Coffee beat Aiglons | Sidama 3-0 | Sidama Coffee |
| Djoliba 2-2 Club Africain | Club Africain 3-2 | Club Africain |
| TP Mazembe 3-1 Medeama | Mazembe advance | TP Mazembe |
| Orlando Pirates 3-1 La Cure Waves | Pirates advance | Orlando Pirates |
| APR 3-0 Aigles RDC | APR advance | APR |
| ASEC Mimosas beat ASC Kara | ASEC 3-2 | ASEC Mimosas |
| Horoya beat JS Saoura | Horoya 3-2 | Horoya |
| Power Dynamos 0-1 Al Merrikh | Al Merrikh advance | Al Merrikh |
| Petro de Luanda 2-2 UD Songo | Petro advance | Petro de Luanda |
| Rangers beat Sobemap on penalties | Rangers advance | Rangers International |
| African Stars 2-0 Mangasport | 3-3, Stars on away goals | African Stars |
| Medina United 1-1 Star Sport Academy | 1-1, Star Sport on away goals | Star Sport Academy |
| Rivers United 2-2 San Pedro | 3-3, San Pedro on away goals | San Pedro |
| Nouadhibou vs Vipers | Level, Nouadhibou on away goals | FC Nouadhibou |
| Stade Malien vs Colombe | 0-0 agg, Colombe 4-3 on pens | Colombe |
Rivers United were eliminated despite coming from two goals down in Uyo. Rangers go through to face MC Alger. Pyramids and Simba posted the heaviest aggregates of the weekend.