Winners over two legs advance to the second preliminary round in October, where they will meet clubs including Mamelodi Sundowns, Espérance de Tunis and RS Berkane, who received byes.
Saturday, 12 September 2026
| Time (WAT) | Match | Venue | Aggregate |
|---|---|---|---|
| 14:00 | African Stars vs AS Mangasport | Lucas Masterpieces Moripe Stadium, Pretoria | Mangasport lead 3-1 |
| 14:00 | Al Hilal Omdurman vs Aigle Noir Makamba | Stade Amahoro, Kigali | Al Hilal lead 2-0 |
| 14:00 | Heegan vs El Merriekh Bentiu | Juba National Stadium | El Merriekh lead 1-0 |
| 14:00 | Nsingizini Hotspurs vs Scottland Mabvuku | Somhlolo National Stadium, Lobamba | Scottland lead 1-0 |
| 14:00 | Orlando Pirates vs La Cure Waves | Orlando Stadium, Johannesburg | Tied |
| 14:00 | Power Dynamos vs Al-Merrikh | Levy Mwanawasa Stadium, Ndola | Al-Merrikh lead 1-0 |
| 15:00 | Lijabatho vs CFFA | Dobsonville Stadium, Soweto | CFFA lead 2-0 |
| 15:00 | TP Mazembe vs Medeama | Stade TP Mazembe, Lubumbashi | Mazembe lead 1-0 |
| 16:00 | Petro de Luanda vs UD Songo | Estádio 11 de Novembro, Luanda | Petro lead 1-0 |
| 16:00 | Rahimo FC vs Maghreb de Fès | Stade du 4-Août, Ouagadougou | MAS Fès lead 4-1 |
| 17:00 | Djoliba vs Club Africain | Stade Mamadou Konaté, Bamako | Club Africain lead 1-0 |
| 17:00 | Young Africans vs Gaborone United | Benjamin Mkapa Stadium, Dar es Salaam | Tied |
| 17:30 | Medina United vs Star Sport Academy | Independence Stadium, Kanifing | Tied |
| 18:00 | Zamalek vs AS Port | Cairo International Stadium | Zamalek lead 2-1 |
| 20:00 | MC Alger vs ASN Nigelec | Ali La Pointe Stadium, Douera | Tied |
Pirates, Yanga, Medina United and MC Alger all go into the second legs level and must win or progress on away goals or penalties.
Zamalek hold a one-goal advantage after Chico Banza and Mohamed Shehata scored in Djibouti. Five-time winners TP Mazembe lead Medeama by a single goal in Lubumbashi.
Sunday, 13 September includes Rivers United vs San Pedro in Uyo (tied 1-1), Simba vs Mighty Wanderers, ASEC Mimosas vs ASC Kara and Pyramids vs Gor Mahia.