Mikel Arteta's side head into the contest knowing that a positive result against one of their biggest rivals would further underline their title credentials, while Liverpool will be determined to use home advantage to reduce the gap at the top of the table.
The match is scheduled to kick off at 4:30pm GMT (5:30pm Nigerian time).
Arsenal seek response after Fleetwood humiliation
Arsenal arrive at Anfield following a disappointing Carabao Cup exit against League One side Fleetwood Town.
The Gunners were held to a 1-1 draw before suffering a 5-3 defeat in the penalty shootout, bringing an embarrassing end to their involvement in the competition.
The result was a major setback for Arteta, particularly as Arsenal were expected to progress comfortably against lower-league opposition.
However, their league form has been considerably better. Arsenal defeated Everton 2-0 in their previous Premier League outing, recording their seventh victory in eight league matches to maintain their position at the summit with 21 points.
The north London club will therefore be eager to put their cup disappointment behind them and deliver a strong performance against Liverpool.
Liverpool arrive in impressive form
Liverpool will approach Sunday's encounter with renewed confidence after recording five consecutive victories across all competitions.
Andoni Iraola's men defeated Brighton 2-0 in their previous Premier League fixture before overcoming Chelsea in the Carabao Cup fourth round.
The encounter against Chelsea ended 1-1 after normal time, but Liverpool secured a 6-5 victory in the penalty shootout to advance to the next round.
The Reds have also enjoyed an impressive run at Anfield against Arsenal, remaining unbeaten in their last 16 home matches against the Gunners across all competitions.
Arsenal's most recent Premier League victory at Anfield came in September 2012, when Lukas Podolski and Santi Cazorla scored in a 2-0 win.
That record presents another difficult challenge for Arteta's side as they attempt to secure a statement result.
Arsenal team news
Arsenal will be without Bukayo Saka, who remains sidelined with a quadriceps injury, while William Saliba is also expected to miss the encounter through a back problem.
Teenage midfielder Max Dowman is suspended following his red card against Fleetwood Town, with his appeal against the dismissal unsuccessful.
Noni Madueke is a doubt after missing the cup fixture with an ankle injury. Arteta is expected to make a late decision on his availability following his fitness assessment.
There is better news for the Gunners, with Declan Rice, Riccardo Calafiori and Christos Tzolis returning to training and expected to be available.
Liverpool team news
Liverpool have injury concerns of their own ahead of the encounter.
Dominik Szoboszlai and Victor Munoz are being assessed after sustaining injuries in the previous weeks, although both players have a chance of returning.
Jeremie Frimpong remains unavailable with a muscle injury, while Conor Bradley, Hugo Ekitike and Giovanni Leoni are also expected to miss the match.
Florian Wirtz, Alexander Isak and Bradley Barcola are among the attacking options expected to feature after Liverpool's midweek cup involvement.
Key battle to watch
The contest between Arsenal's midfield and Liverpool's attacking unit could prove decisive.
Declan Rice's ability to protect the defence and control the central areas will be important for the visitors, particularly against Liverpool's pressing and forward movement.
Arsenal will also need to be clinical in front of goal, while Liverpool are expected to exploit the pace and movement of their attacking players.
With both sides possessing considerable attacking quality, the encounter promises to be an intense battle with significant implications for the title race.
Match details
Competition: English Premier League
Fixture: Liverpool vs Arsenal
Date: Sunday, November 1, 2026
Venue: Anfield, Liverpool
Kick-off: 4:30pm GMT (5:30pm Nigerian time)
Arsenal's objective: Extend their advantage at the top of the table.
Liverpool's objective: Close the gap on the league leaders.
Prediction
Arsenal's stronger league campaign makes them dangerous opponents, but Liverpool's recent form and impressive home record against the Gunners make this a difficult fixture to call.
A closely contested encounter is expected, with both teams capable of finding the net.
Nigfooty Sports Desk prediction: Liverpool 1-1 Arsenal.