The Charlotte FC defender earned 86 caps for the US national team and won two CONCACAF Nations League titles during a distinguished 16-year international career.
Ream captained the side at this year’s World Cup on home soil, where the United States reached the last 16 before being eliminated by Belgium.
“That’s it for me. I’m proud of being part of something for 16 years, but it is time to step away from the national team,” Ream told reporters ahead of Tuesday’s friendly against Chile in his hometown of St. Louis, Missouri.
The former Fulham and Bolton Wanderers player received an emotional pre-game send-off before the match, which the US went on to win 4-2.
Ream’s retirement marks the end of a long and reliable presence at the heart of the American defence. The national team now turns its attention to upcoming fixtures against Mexico and Canada as a new chapter begins without one of its most experienced leaders.