Level 1 – 8 Top-ranked Clubs (Exempted)
These clubs will enter the competition directly in the second preliminary round:
- Al Ahly SC 🇪🇬
- Azam FC 🇹🇿
- USM Alger 🇩🇿
- AS FAR 🇲🇦
- CR Belouizdad 🇩🇿
- Raja CA 🇲🇦
- AS Maniema 🇨🇩
- Kaizer Chiefs 🇿🇦
Level 2 – 8 Ranked Clubs
- Al Ahly Tripoli 🇱🇾
- Singida Black Stars 🇹🇿
- CS Sfaxien 🇹🇳
- AS Real Bamako 🇲🇱
- ASKO de Kara 🇹🇬
- Jwaneng Galaxy 🇧🇼
- A. Black Bulls 🇲🇿
- CD 1º de Agosto 🇦🇴
Level 3 – 40 Non-ranked Clubs
- Kabuscorp do Palanca 🇦🇴
- Rukinzo FC 🇧🇮
- Panthère Sportive 🇨🇲
- Atomic Ngome 🇰🇲
- DC Virunga 🇨🇩
- Green Mamba 🇸🇿
- FC Rouge 🇲🇬
- AS Port Louis 2000 🇲🇺
- UNAM FC 🇳🇦
- Rayon Sports FC 🇷🇼
- PTL Bazar Brothers 🇸🇨
- Durban City FC 🇿🇦
- Red Arrows FC 🇿🇲
- ASAS Djibouti Télécom 🇩🇯
- ZED FC 🇪🇬
- Welwalo Adigrat 🇪🇹
- Tusker FC 🇰🇪
- Mogadishu City Club 🇸🇴
- Al-Ghazala FC 🇸🇸
- Al Hilal Alsahil 🇸🇩
- Al Ahli Madani 🇸🇩
- Kitara FC 🇺🇬
- KMKM SC
- ASPAC FC 🇧🇯
- Vitesse FC 🇧🇫
- AS PSI 🇹🇩
- AF Amadou Diallo 🇨🇮
- CO de Korhogo 🇨🇮
- The Panthers FC 🇬🇶
- Nations FC 🇬🇭
- Hafia FC 🇬🇳
- UDIB 🇬🇼
- FC Diarra 🇲🇱
- AS Douanes 🇲🇷
- AS ZAM 🇳🇪
- El Kanemi Warriors 🇳🇬
- Shooting Stars SC 🇳🇬
- Diambars FC 🇸🇳
- East End Lions FC 🇸🇱
- ES de Zarzis 🇹🇳
A total of 56 clubs will compete for places in the group stage of the CAF Confederation Cup.