Roma delivered a strong first-half performance at the Stadio Tre Fontane, scoring twice through Kayleigh van Dooren and Alayah Pilgrim before holding off a late challenge from the visitors.
The hosts broke the deadlock in the 25th minute when Van Dooren found the back of the net to give Roma a deserved lead.
Nine minutes later, Pilgrim doubled their advantage, putting the Italian side in a comfortable position heading into the half-time break.
Servette fight back but Roma hold firm
Servette returned for the second half determined to get back into the contest and gradually increased their attacking pressure.
Their efforts paid off in the 74th minute when Gloria Marinelli converted a penalty to reduce the deficit to 2-1.
The goal gave the Swiss visitors renewed hope of securing a point, but Roma remained organised defensively and successfully protected their advantage until the final whistle.
Important result for Roma
The victory represents a significant boost for Roma as they continue their campaign in Europe's premier women's club competition.
After struggling to collect points in their opening matches, the Italian side will hope the result provides the momentum needed to improve their position in the league-phase standings.
Servette, meanwhile, will be disappointed to leave Rome without a point after their second-half response failed to produce an equaliser.
Full-time: AS Roma Women 2-1 Servette Women
Competition: UEFA Women's Champions League, 2026/27 league phase.
Venue: Stadio Tre Fontane, Rome, Italy.
Goals:
Roma: Kayleigh van Dooren 25', Alayah Pilgrim 34'.
Servette: Gloria Marinelli 74' (penalty).