Ronnel Donnelly was the star of the evening, scoring a superb hat-trick to inspire the South African champions to victory and keep their hopes of another continental title alive.
Donnelly's outstanding performance proved decisive as Sundowns demonstrated their attacking quality against the Ugandan side, scoring four goals to book their place in Sunday's final.
Kawempe Muslim Ladies managed to find the net once, but their effort was not enough to stop Sundowns from advancing.
ASFAR await Sundowns in the final
Sundowns will now face Moroccan giants ASFAR in the final, setting up a meeting between two of Africa's leading women's football clubs.
The final is scheduled for Sunday at 17:00 local time.
Sundowns will be targeting another CAF Women's Champions League crown, while ASFAR will be determined to stand in their way and claim continental glory.
With Donnelly in impressive scoring form, the South African side will approach the final with confidence as they prepare for a challenging encounter.