Several big sides have already secured useful away wins, while a few ties remain finely balanced.
Results So Far (First Legs)
Friday 16 October
• El Merriekh Bentiu (South Sudan) 0-1 Pyramids FC (Egypt)
• APR FC (Rwanda) 0-1 Zamalek (Egypt)
• Star Sport Academy (Sierra Leone) 0-2 RS Berkane (Morocco)
Saturday 17 October
• CFFA (Madagascar) 0-4 Young Africans (Tanzania)
• African Stars (Namibia) 0-1 Orlando Pirates (South Africa)
• TP Mazembe (DR Congo) 1-1 Club Africain (Tunisia)
• San Pedro (Côte d’Ivoire) 2-1 FC Nouadhibou (Mauritania)
Remaining First-Leg Fixtures
Sunday 18 October
• Rangers International (Nigeria) vs MC Alger (Algeria)
• Scottland FC (Zimbabwe) vs Petro Atlético (Angola)
• Sidama Bunna (Ethiopia) vs Al Hilal Omdurman (Sudan)
• Wiliete (Angola) vs Mamelodi Sundowns (South Africa)
• Horoya AC (Guinea) vs Al-Merreikh (Sudan)
• Al-Swehly (Libya) vs Espérance de Tunis (Tunisia)
• Teungueth FC (Senegal) vs Colombe Sportive (Cameroon)
• Maghreb Fès (Morocco) vs ASEC Mimosas (Côte d’Ivoire)
Tuesday 20 October
• 15 de Agosto (Equatorial Guinea) vs Simba SC (Tanzania)
The return legs are scheduled for 23–25 October. The 16 winners on aggregate will advance to the group stage of Africa’s premier club competition.