The visitors took the lead in the seventh minute through Stephen Amankona, who capitalised on a costly error to put Aduana ahead. Despite being reduced to 10 men later in the contest, the visitors defended resolutely and frustrated the Porcupine Warriors for long periods.
Kotoko dominated possession after the break but failed to convert their chances. Aduana sealed the victory deep into stoppage time when Seidu Saana finished a swift counter-attack in the 90th minute, completing a memorable away win.
The result leaves Asante Kotoko with five points from four matches after an otherwise solid start to the campaign.
Elsewhere, Hearts of Oak also tasted defeat for the first time this season, losing 1-0 to Karela United. The Phobians were unable to break down a stubborn Karela side and paid the price for a lack of cutting edge in front of goal.
In another high-scoring encounter, Medeama produced a dominant performance to thrash Holy Stars 4-1. The Mauve and Yellows were clinical in attack and took full advantage of their opportunities to claim a convincing victory.
The weekend’s results mixed the early standings, with several traditional powerhouses dropping points while other sides capitalised. Aduana’s win against Kotoko stands out as one of the surprises of Matchday Four, while Medeama’s emphatic result underlined their attacking threat.
The Ghana Premier League continues to deliver competitive and unpredictable action as teams settle into the new season. Attention now turns to the next round of fixtures as clubs look to build momentum or recover from early setbacks.