The two-legged tie presents a stern test for Medeama against one of Africa’s most successful clubs. TP Mazembe have a rich continental pedigree and will be strong favourites to progress.
The winner of the encounter will advance to the second preliminary round, where they will meet either Club Africain of Tunisia or Djoliba AC of Mali.
The draw sets up a challenging path for Medeama as they begin their campaign in Africa’s premier club competition. Both ties will be played over two legs, with the aggregate winners progressing towards the group stage.