The 23-year-old Getafe player sustained the damage during a pre-season friendly against AS Monaco. Further medical tests confirmed several breaks in the knee, along with tears to both ligaments and the meniscus.
Uche will undergo surgery in the coming days and faces a lengthy rehabilitation process. The diagnosis rules him out of the full campaign for club and country.
The setback comes after the Super Eagles international returned to Getafe following a loan spell at Crystal Palace last season. He had been expected to play a significant role under coach José Bordalás this term.
